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Lumbrokinase: The Potential Benefits Of An Earthworm Extract

An image of someone holding an earthwormThe majority of health issues faced by people these days stems from the adrenals. Your adrenal glands responsible for so many health functions and become overtaxed with the lifestyle most of us currently enjoy. Yet this same lifestyle may, not only cause harm to the adrenals but result in a variety of disorders affecting the brain, heart, gastric system, and all our hormonal processes. According to research, lumbrokinase, an extract commonly used in Traditional Chinese Medicine, may have many health benefits addressing some of these issues.

Lumbrokinase, according to Traditional Chinese Medicine, may address liver, spleen, lung, and circulatory health issues. And western research is increasingly finding truth in these claims while adding many more benefits.

What Is Lumbrokinase?

Lumbrokinase is an enzyme with fibrinolytic and proteolytic properties. It helps prevent blood clotting because it breaks down fibrinogen, the protein associated with blood clotting. While blood clotting is necessary for wound healing, you may, in some instances, need to prevent blood clot formation like deep vein thrombosis or stroke.

In traditional Chinese medicine, lumbrokinase is derived from earthworms, specifically Lumbricus rubellus species. Practitioners would make a tea from these ground-up earthworms and use for various health issues, although a powdered form of the extract became more commonplace.

Western medicine started paying attention and, in 1980, identified a specific enzyme, i.e. lumbrokinase, and its various potential health benefits investigated.

Although considered a supplement, the lumbrokinase sold these days typically do not come from crushed up earthworms. Instead, using recombinant gene technology, products such as RNA buluoke or lumbrokinase RNA are created with the same properties. In so doing, higher volumes of this enzyme are manufactured and ensure a higher supplement volume. The process also helps to keep down costs as a 100% earthworm-derived lumbrokinase supplement is quite expensive.

General Benefits Of Lumbrokinase

Lumbrokinase may be of great benefit to those suffering from certain conditions commonly associated with adrenal fatigue. Adrenal fatigue is a component often overlooked in many health issues, including hormone imbalance, diabetes, fibromyalgia, heart disease, numerous psychological conditions, and more. But not only may adrenal fatigue contribute to the development of these health issues. Indeed, these health issues may also contribute to an increase in your adrenal fatigue symptoms.

Lumbrokinase And Adrenal Fatigue

Lumbrokinase may have many benefits for those with adrenal fatigue and address many of the issues associated with the condition. Interestingly, studies suggest that it may have antioxidative, anti-ulcer, antibacterial, and anti-carcinogenic properties as well. These various properties may benefit not only those with adrenal fatigue but also many of the health issues associated with the condition.

Fighting Inflammation

An image of a woman holding her midsection in painOne of the main causes of many of the adrenal fatigue-related health issues is inflammation. Unhealthy blood coagulation and an increase in fibrinogen often precede inflammation. An increase in fibrinogen levels is also often associated with Adrenal Fatigue Stage 2. Fibrinogen handles your blood’s clotting ability.

Lumbrokinase, as mentioned, could decrease blood clot formation. This it does by addressing elevated fibrinogen levels. By bringing fibrinogen levels down, lumbrokinase may provide the support your body needs to decrease your inflammatory response and thus address some of the issues associated with adrenal fatigue and its various symptoms.

Antioxidant Properties

Antioxidants protect your body from the damaging effect of free radicals and the oxidative process. Earthworm extracts hold large concentrations of antioxidants and enzymes that support the body and fight free radicals and the effects of oxidative stress. It may also promote gastric health by protecting gastrointestinal mucus membranes, preventing the formation of ulcers, and decreasing stomach acidity.

Gastric Health

Earthworm extracts may also have antibacterial properties and support gastric health by helping reduce bad bacteria in your digestive tract.

Gastric health plays an important role in your immune function and is related to adrenal fatigue and its associated symptoms. Gut health is vital to adrenal health as it helps to ensure proper absorption of nutrients in the healing process.

Potential Benefits Of Lumbrokinase For Specific Health Issues Related To Adrenal Fatigue

The main benefit thus far associated with lumbrokinase is its antithrombotic properties. Thrombocytes, i.e. platelets, are red blood cells that tend to stick together where damage occurs to stop bleeding. Lumbrokinase inhibits this sticking-together tendency of the platelets and may be useful during conditions when you do not want this to happen. This makes lumbrokinase, a possible contender instead of anticoagulant drugs like warfarin, for example.

This coagulant property may be of great use in addressing several specific health conditions.

Diabetic Nephropathy

Diabetic nephropathy refers to kidney damage resulting from diabetes. High blood sugar levels resulting from diabetes may damage your kidneys and hamper their blood filtering abilities. This results in an accumulation of protein in your urine. Diabetic nephropathy is one of the main causes of kidney failure. The condition may result due to a combination of poor diabetic control and high blood pressure.

Symptoms associated with the condition include:

  • Fatigue
  • Feeling under the weather without knowing why
  • An image of a woman sitting with her arms crossed while she looks at a plate of untouched foodLoss of appetite
  • Weight loss for no apparent reason
  • Muscle cramps
  • Dry and/or itchy skin
  • Puffiness in the eye area
  • Concentration difficulties
  • Fluid retention resulting in swollen ankles and feet

According to research, lumbrokinase may help with diabetic neuropathy by improving kidney function. Kidney function often sees a decline when suffering from adrenal fatigue, partly due to toxic buildup and the kidney’s inability to deal with the issue.


Lumbrokinase may be of benefit to those suffering from angina, according to research.

Angina, a common symptom associated with coronary heart disease, is a chest pain resulting from reduced blood flow to your heart.

People with angina may experience:

  • Chest pains or discomfort, as well as feelings of burning, added pressure, or fullness in the chest area
  • Pain in your shoulder, arms, neck, back, or jaw
  • Dizziness
  • Nausea
  • Breathing difficulties
  • Sweating
  • Fatigue

Research shows that the use of lumbrokinase may help address most of the issues and symptoms associated with angina, a health issue often associated with adrenal stress.


According to research, lumbrokinase may aid in recovery from ischemic stroke. This is the most common type of stroke and is associated with a blockage in blood vessels in your brain. Such a blockage prevents oxygen from reaching the brain and results in brain cells dying off. However, make sure you check with your doctor regarding the type of stroke because you don't want to take a blood thinner if you have a type of stroke that is hemorrhagic.

Another cause of an ischemic stroke is stenosis and refers to the narrowing of an artery in the brain.

Symptoms associated with a stroke include:

  • Experiencing trouble with speaking or slurring your words
  • Difficulty in understanding what people are saying
  • Paralysis or numbness in your arms, legs, or facial muscles often affecting only one side of your body
  • Sight issues like seeing double or blurred vision
  • Developing a sudden, severe headache often accompanied by dizziness or vomiting
  • Balance problems that may affect your walking

Research strongly suggests that supplementing with lumbrokinase may:

  • Speed up your recovery time after a stroke
  • Improve blood circulation in your arteries
  • Reduce your chances of developing repeat strokes
  • Increase your overall chances of survival
  • Result in fewer unstable plaques that cause arterial obstructions or narrowing of arteries

Coronary Artery Disease

Coronary artery disease refers to the narrowing or blockage of coronary arteries. This is usually due to atherosclerosis, i.e. the buildup of cholesterol and plaques on your arteries’ inner walls. In so doing, the hampered blood flow to the heart may cause damage to both artery and heart function.

This condition may result in inadequate blood supply to the heart which means the heart does not receive the oxygen and nutrients it needs to work properly. Besides resulting in angina, a heart attack may ensue.

Symptoms associated with coronary artery disease include, besides angina:

  • Nausea
  • Sweating
  • Dizziness
  • General feelings of weakness
  • Shortness of breath
  • Heart palpitations (arrhythmia)

Evidence suggests that lumbrokinase may help with coronary heart disease and its symptoms by improving blood flow, reducing arrhythmia, and improving cardiovascular blood markers.

A Word Of Caution When Considering Lumbrokinase As A Supplement

An image of supplements poured onto a wooden spoonResearch into the suitability of lumbrokinase in addressing certain health issues is still ongoing and not much is known as to its possible interaction with medications. What is known, is that a small percentage of the population may have certain side effects when using this supplement. These include constipation, headaches, nausea, and headaches.

Because of its anti-coagulant abilities, however, people with bleeding disorders like hemophilia should rather not use this supplement. You should also not use it if you have a surgery scheduled as it may worsen bleeding.

For safety reasons, please talk to your healthcare professional before using lumbrokinase as they could advise you as to its safety and dosage.

In Closing

Although research into earthworm extract and lumbrokinase is still ongoing, it shows that the health supplement may have many beneficial properties covering various health conditions.

If suffering from heart health issues or adrenal fatigue, here are a few things you can do to help alleviate the situation.

  1. Explore the use of lumbrokinase with your primary healthcare practitioner.
  2. Make sure to source the product from an accredited provider.
  3. Find out whether the product has any possible contraindications with regards to any medications you are currently using.

If you would like to know more about lumbrokinase and its use for your specific health issue, the team at Dr. Lam Coaching can help. We offer a free** no-obligation consultation at +1-626-571-1234 where we will privately discuss your symptoms and various options. You can also send us a question through our Ask The Doctor system by clicking here.

© Copyright 2021 Michael Lam, M.D. All Rights Reserved.

Dr. Lam's Key Question

There is no single quick cure for adrenal fatigue, a condition that develops over a long period and which has many possible negative influences. But because of the potential benefits lumbrokinase holds, it may help support adrenal health while addressing some of the health issues associated with the condition.

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