Video summarized in article below.Ā
Dr. Michael: Okay. So, letās start with understanding what inflammation really is. Now, itās quite interesting that up to 30 years ago the concept of inflammation as being something that is bad for our body has never been really explored. We know that inflammation is part of a normal physiological response.
Letās say you sprain your ankle. Itās going to turn red. Itās going to swell up. Itās going to be hot. Youāre going to have pain, and youāre going to have a loss of function. This is all part of the bodyās inflammation response, and we know it is a good thing.
Now, the problem really comes when the bodyās inflammation responseāand we will go into thatābecomes kind of haywire. So, letās start out firstā¦ Dr. Jeremy, tell us more about inflammation.
Dr. Jeremy: So, inflammation is classically characterized by, like you said Dr. Lam, redness, heat, swelling, pain, and loss of function. So, again, inflammation is a normal part of your bodyās defenses. For example, your body has a fever when it comes into contact with a virus or a foreign pathogen because itās trying to get rid of that foreign pathogen, and itās harder for viruses and bacteria to survive at higher temperatures. The fever also helps activate the bodyās immune system, which is one important part of the Inflammation circuit. So, again, inflammation is not a bad thing, but if it becomes chronic, then long-term problems can start to arise.
Now, before we talk about the Inflammation circuit Dr. Lam, why donāt you just tell us about the whole NeuroEndoMetabolic stress response in relation to the Inflammation circuit.
Dr. Michael: Okay. Now, our body is designed and has evolved through all these years to adapt to the environment whenever thereās stress. Now, stress can be physical or emotional. In the old days, stress meant that you had to face a tiger that was running after you and trying to eat you up. In modern days, stress is really about more emotional than physical stress. However, the body doesnāt understand that.
The bodyās reaction to stress is the same, and it actually has three components. One is the neurological system that kicks in. One is the endocrine system that kicks in. And one is the metabolic system that kicks in. I say those words loosely, but each of these components is actually multi-compartmentalized.
When you combine these three things together, you get what we call the NeuroEndoMetabolic stress response. Itās like an orchestra with the winds section, the strings section, and the percussions. So, when you have all these three work together, they orchestrate an overwhelming, well-designed, perfect response to any stress when it comes. So, this stress responseāwhich we call NeuroEndoMetabolic stress response or the NEM stress responseāhas six different circuits. Each circuit is responsible for a certain part of the response and is activated at a certain time and sequence to help the body deal with stress.
They are the Inflammation circuit, the Detoxification circuit, the Hormonal circuit, the Bioenergetic circuit, the Cardionomic circuit, and the Neuroaffect circuit. Now, today weāre going to focus more on the Inflammation circuit.
So, the body combines these circuits, and they activate it at certain times in perfect sequence. Sometimes itās the Inflammation circuit. Sometimes the Cardionomic circuit. Sometimes it is the Detoxification circuit. Collectively, they form a wonderful symphony with a design to prevent the body from being overcome by stress.
If the stresses however become too big, then these circuits can therefore become compromised. They become dysregulated, or they can be damaged or broken. Thatās when the signs and symptoms happen. Dr. Carrie letās talk about specifically the Inflammation circuit.
Dr. Carrie: Right. The Inflammation circuit is regulated by three main organ systems. The first is the immune system, the second is the GI tract, and the third is the microbiome. These three systems are the Inflammation circuit of the NeuroEndoMetabolic stress response, because inflammation like we talked about, is a normal defense mechanism of the body. It can be designed to protect you, but like Dr. Lam said, if it goes on for too long, youāre in the fight or flight stage, and youāre just starving. Or having too much chronic stress, it can lead to stressing the body and the adrenal glands. So, Dr. Jeremy why donāt you tell us about each organ system in more detail.
Dr. Jeremy: Okay. So, the first organ is actually the immune system. Inflammation at its heart is really the immune response in the body. When your body is under attack, the immune system will release these inflammatory compounds, which will help deal with an invasion and foreign pathogens.
Now, after the attack, your inflammation comes down and things go back to normal. This is a normal response.
However, if your body and your immune system is constantly being stressed, constantly being attacked, then the inflammation can become chronic, and this could lead to problems.
Now, the immune system over time can be put into overdrive leading to some immune-related issues such as autoimmune conditions, getting sick often, and constantly feeling under the weather. These are some of the types of issues that can happen when your immune system is just put on overdrive.
Dr. Carrie: So, long-term inflammation from the immune system will actually result in symptoms as well, like migrating aches and pains, itchiness, fatigue. All right?
The second system that could really get affected would be the GI tract. The GI tract is very important in your bodyās defense mechanism to prevent inflammatory compounds from entering your system.
But if your gut is not doing well, it can add to this inflammation, and actually make things more inflammatory in nature.
Some foods are more suspect than others. These include sugars, refined grains, alcohol, processed meats, and dairy. So these are definitely foods you want to avoid.
Dr. Michael: So, the concepts that weāve talked about so far, the immune system and the GI tract, both form the cornerstone of the inflammation response. So, the GI tract is such an important system in the inflammation response of our body. Dr. Carrie, let us know what problems happen when the GI tract becomes inflamed.
Dr. Carrie: You could have a lot of conditions and symptoms that can arise due to GI tract imbalance. These include leaky gut, getting a lot of diarrhea or gas or bloating, food sensitivities, fatigue after eating like a food coma, changes in your mood, and even anxiousness.
Dr. Michael: Yes. Most people donāt really associate these things with the inflammation response, but if you look globally, itās almost like the body is on fire. Thereās a simmering discontent within. Itās this ongoing displeasure that drains the system. Itās almost like someone is hitting you constantly, 24/7, even though youāre sleeping, and sooner or later your body wears out. Thatās why these symptoms occur.
Dr. Jeremy letās go on to the third part of the inflammation circuit. We talked about the immune system. We talked about the GI tract. What is the third part?
Dr. Jeremy: Okay, so the third and final system of the inflammation circuit is the microbiome. The microbiome is a combination of microorganisms that help us stay alive. They protect us against germs. They help break down our food. They produce vitamins for our bodies, and they also help control our immune system.
So we have many microbiomes in many locations, such as our stomach, our intestines, on our skin. Even on the vagina and in our nasal passages we have microbiomes.
Dr. Michael: Of course, one of the most important microbiomes is actually lining the gut. It is the imbalance of this microbiome that leads to what we call āgut dysbiosis.ā So symptoms can be like feeling gassy, bloating, leaky gut, weight gain, or imbalanced blood sugar.
Most people think of inflammation as just a redness which is true, but thereās a chronic subclinical inflammation that goes on that you donāt see. Itās this that drains you. No matter what you do, you just donāt seem to have your full vitality. This is what inflammation imbalance can lead to.
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