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Synapsin: A Promising Medication for Brain Fog, Fatigue, and More

An image of two nasal spraysSynapsin is a nasal spray that may help boost concentration and reduce brain fog symptoms. Many people find themselves under chronic stress these days, which leads to brain fog, fatigue, and difficulty concentrating and could interfere with professional and personal life. By making it easier to focus and concentrate, Synapsin could help reduce stress and improve your quality of life. However, it requires a special prescription and a special kind of pharmacy to mix it.

What Is Synapsin?

Synapsin is a nasal spray compound that could help promote neuronal function in the brain and help improve neurocognitive disorders.

The active ingredients in Synapsin are ginsenosides, which are certain steroid glycosides and triterpene saponins. The ginsenosides in Synapsin have a low bioavailability after being taken orally. When taken through the nasal cavity, however, these ginsenosides cross the blood-brain barrier where they have a beneficial effect on the brain’s microglial cells. These cells, found in the central nervous system, remove damaged neurons and fight infections.

Synapsin Ingredients

Synapsin nasal spray contains three main ingredients.

Ginsenoside Rg3

Ginsenoside Rg3, a compound of Red Panax ginseng, promotes brain health in numerous ways. It may promote the survival of neurons, help address oxidative stress resulting from free radical actions, reduce damage to lipids or molecules containing them, and inhibit N-methyl-D-aspartate (NMDA) and non-NMDA receptors that contribute to various neurological conditions. Literature also indicates ginsenoside Rg3 may also block an increase in cortisol production, improve immune function, fight cancer, and improve your brain’s neurotransmission ability.

Nicotinamide Riboside

Also referred to as niagen or niacin, nicotinamide riboside is a form of vitamin B3. We find it in cows’ milk, chicken, beef, and turkey, amongst others. This vitamin, often suggested as an anti-aging supplement, raises your body’s nicotinamide adenine dinucleotide (NAD+) levels. NAD+ is a coenzyme, a helper molecule with strong neuroprotective effects, especially for those with lower tryptophan levels. NAD+ helps deal with neuroinflammation, converts food into energy, repairs damaged DNA, and sets your circadian rhythm. It also helps promote immune health. NAD+ levels in the brain tend to decrease with age or when you suffer from a chronic neuroinflammatory condition.

Nicotinamide riboside also plays a role in sirtuin expression regulation, which controls your metabolism and improves the metabolic processes in a cell’s mitochondria.


Methylcobalamin is a form of vitamin B12 commonly used as a supplement in those with a vitamin B12 deficiency. It is important for axonal nerve regeneration and neuronal lipid production. It also shows strong neuroprotective activities.

Methylcobalamin helps in the production of myelin. Myelin is a sheath that covers and protects nerve fibers and helps protect against various health issues resulting from nerve damage, whether in the brain or other areas of your body. It thus plays a significant role in brain health and function.

Nasal Spray For Fast Delivery

An image of a bottle of nasal sprayOral medications reach your bloodstream only after they have reached your gastrointestinal tract. The digestive process then starts, and the benefits of the medications must first pass through your intestinal wall before reaching the bloodstream. This is why it may take up to thirty minutes before they start working. Furthermore, they have a systemic action, meaning your blood spreads their benefits throughout your body.

A nasal spray, on the other hand, almost immediately starts working in the intended area. In the case of Synapsin, the spray crosses the blood-brain barrier and goes to work on the brain.  Thus the beneficial effects of this spray are almost immediate.

Benefits of Synapsin

Because it is a nasal spray, the different components easily cross the blood-brain barrier. This means you feel the spray’s benefits almost immediately. The components in Synapsin have many beneficial neurological benefits and may also help with fatigue symptoms and inflammation.

Health issues that may benefit from the use of Synapsin include, amongst others:

  • Autism spectrum disorder (ASD)
  • Health issues resulting from mold exposure
  • A traumatic brain injury
  • Stroke or transient ischemic attack (TIA)
  • Diabetes
  • Alzheimer’s
  • Parkinson’s disease
  • Attention deficit hyperactivity disorder (ADHD)
  • Chronic stress
  • Post-concussion syndrome
  • Seizures
  • Lyme disease
  • Chronic inflammatory response syndrome (CIRS)
  • Amyotrophic lateral sclerosis (ALS)
  • Adrenal fatigue

In addition, over 76% of people with fibromyalgia, an autoimmune disorder, suffer from chronic fatigue. Synapsin may provide a measure of relief for people suffering from this condition. Literature shows the various components in Synapsin also have antioxidant and anti-inflammatory properties.

Neuroaffect Issues and Stress

Your Neuroaffect Circuit forms part of your NeurEndoMetabolic (NEM) stress response which is your body's primary response to stress and is governed by the Hypothalamic-Pituitary-Adrenal (HPA) axis. The Neuroaffect Circuit itself is made up of your brain, autonomic nervous system, and microbiome. This means that your body’s response to stress and the various health issues resulting from it starts in your brain. The Neuroaffect Circuit is also primarily responsible for helping you deal with any emotional or mental issues that may crop up.

Your HPA makes use of neurotransmitters to facilitate any action in response to stress. This includes your fight or flight response and the corresponding increased call for cortisol production in the adrenal glands. If this state of stress perseveres, the elevated demand for cortisol persists and even increases. This could lead to the disruption of various organs and systems that include your hormone production, gut health, and immune system.

Many of these health issues are, in fact, symptoms of adrenal fatigue. Adrenal fatigue commonly happens when chronic stress wears down the ability of the adrenals to respond. This causes widespread symptoms. These include issues that affect your brain health such as brain fog, poor concentration, and fatigue.

Because Synapsin has many beneficial properties regarding brain health, it may result in the quick delivery of beneficial support close to where it is needed – your brain.

How to Take Synapsin

Typical administration involves two sprays into each nostril daily. In some cases, your healthcare professional may advise two sprays twice daily. The maximum dosage per day is two sprays three times daily.

Most people show a marked improvement in their symptoms after using Synapsin after a few weeks, but it may depend on their health needs. Many people using this spray show an improvement much sooner. Do remember, though, that this nasal spray is an aid in dealing with symptoms only. It does not necessarily address the underlying root cause. You should therefore use the spray as an adjunct to other recommendations given by your healthcare professional for addressing the underlying cause of any health problems.

Possible Synapsin Contraindications

Literature suggests this medication is well tolerated by most. Possible side effects include stinging in your nose after using it and irritation. This usually subsides after a while. Because you need to store this nasal spray in your refrigerator, rolling it in your hands to warm it up before use may help ease the irritation or stinging sensation. Do remember that this medication is red, so take care not to spray too close to your nostrils as some may leak out and cause discoloration in this area.

How To Get Synapsin

Synapsin can only be acquired through a prescription from a qualified natural medicine healthcare practitioner. Once in possession of such a prescription, you would need to collect it from a compounding pharmacy. A compounding pharmacy is one where a trained professional specializing in natural and specialty medications custom-makes medications to suit your individual needs.


Synapsin is a medication made from natural elements that may help address many health conditions resulting from possible brain issues. If you would like to try Synapsin, here is how you can go about doing so.

An image of a man holding his nose

  • Firstly, talk to a qualified practitioner of natural medicine so that they may assess whether it will work for you and to obtain a prescription.
  • Take your prescription to a compounding pharmacy so that they can make up your Synapsin.
  • Talk to your healthcare professional in case of any side effects so that they may adjust your dose accordingly.
© Copyright 2022 Michael Lam, M.D. All Rights Reserved.

Dr. Lam’s Key Question

Synapsin does not work on your adrenal glands directly. It tends to work in your brain by providing support to neuron functions. But by this very action, it may help boost alertness and reduce stress that is caused by inability to function. This may provide indirect adrenal support in some cases.