The adrenal glands are the main stress modulation centers of the body. When stressors (either physical or emotional) overwhelm the adrenals ability to compensate, Adrenal Fatigue may ensue. This is usually a slow and insidious process that progresses through many years, though some can experience it after an intense episode of acute stress, such as the death of a loved one, financial distress, or acute infection.
The job of returning the body to its normal function rests with the adrenals. This process is indeed complicated and convoluted, accompanied by many unpleasant symptoms. They are mediated primarily by hormones. The main ones are cortisol, adrenaline, estrogen, and androgen. The adrenals bear the brunt of this responsibility, as it secretes over 50 different hormones in an exact and very precise manner to maintain normal internal homeostasis. Adrenal hormones, in turn, affect other hormones in the body, ranging from thyroid hormones to serotonin to insulin. The state of dysregulation of these hormones results in unpleasant and abnormal physiological responses during an acute adrenal decompensation episode. It is the body's way of returning to a lower state of physiological function where conservation of energy becomes a primary focus for survival.
Adrenal crash is, therefore, the body's strategy of returning to a state of simple living dominated by bedrest.
If the adrenal's compensatory emergency response effort is successful, the adrenal crash will eventually stop and the body will begin to stabilize and gradually return to its pre-crash state of function through what is known as the Recovery Phase. The Crash and subsequent Recovery Phase taken as a whole constitute the Adrenal Crash and Recovery Cycle. Unpleasant symptoms slowly disappear during the recovery cycle. If not successful, the body will continue to decompensate until such time as external help is rendered to support the adrenals and arrest the crash. In the absence of that, the body will naturally and slowly deteriorate, ultimately resulting in adrenal failure.
Total adrenal failure is a medical emergency, but there are several measurable degrees of Adrenal Fatigue before adrenal failure. These Adrenal Fatigue states (Adrenal Fatigue stages 1-4) usually progress with time and is triggered and exacerbated and marked by periodic adrenal crash and recovery cycles.
This paper will examine the adrenal crash and the recovery cycle in great details as they are found in each of the Adrenal Fatigue stages. Due to the lack of quantitative and laboratory investigative tools, findings presented here is primarily based on the clinician's perspective.
As mentioned above, Adrenal Fatigue is the body's strategy for returning to a simpler physiologic form of function as a way to conserve energy. The more advanced the fatigue, the lower the physiological basis. The most basic physiological state is prolonged bed rest. We call it hibernation in the animal kingdom. When an animal hibernates, it expends a minimal amount of energy. It comes as no surprise that those with adrenal crashes or in advance stages are often bed-ridden.
No organ is spared as the body down-regulates during a crash or as Adrenal Fatigue worsens and the body returns to a simple state. Multiple organ systems are involved. The first systems to turn off are those not required for basic survival. Reproduction is considered a luxury and not a vital function when survival is at stake. Libido, as a result, is lowered. The thyroid also goes into a slow down mode as the body attempts to reduce the basal metabolic rate (idle speed) to conserve energy. This naturally leads to sluggishness, constipation, and worsening fatigue. The gastrointestinal tract as a whole tends to slow down in its assimilation of food. Complex and processed foods become hard to digest and less is absorbed. Digestive enzymes and acid release are reduced. Gastric motility slows. As a result, foods do not churn as much compared to that of a normal healthy person. Poor digestion is common, accompanied by reduced absorption, increased gas, bloating, and constipation.
As this happens, the liver and kidney functions are also affected. Both are the clearing houses of the body's toxins. As liver function slows (though laboratory tests are usually normal), complete breakdown of metabolites becomes compromised. Overall, body clearance of such by-products tends to slow concurrently as toxic metabolite build-up occurs as a result. Fat-based metabolites tend to find their way into areas of the body high in fat as they attract each other. Lipophilic organs (organs that like fat) such as the brain have a tendency to attract such fat based metabolites easily. Instead of a normal complete clearance out of the body on a timely basis, such metabolites tend to accumulate instead. Metabolites that accumulate in the brain can lead to and contribute to memory loss, confusion, anxiety, and brain fog. Normal brain function may be impaired if severe. Some accumulate in joints and muscles, leading to muscle pain of unknown origin and joint inflammation. The number of symptoms becomes overwhelming.
The down-regulation or return to simplicity will continue as long as the body sees it as a positive step to conserve energy for survival. As the body further slows down, muscle breaks down to generate energy, leading to an overall net loss of protein and muscle mass. When this happens, the body enters a catabolic state, with overall weight loss and muscle wasting. Fibromyalgia and chronic fatigue may ensue. Appetite reduces as the gastrointestinal tract motility slows. Those with sugar imbalances and insulin resistances are particularly vulnerable to a worsening state. Electrolyte imbalance becomes common. If the condition does not reverse, the body goes into an alarm reaction, activating the fight or flight response and release of adrenaline. Too much adrenaline can further propagate this viscous downward cycle. The normal negative feedback loop of hormones derails and soon a less stable positive feedback loop replaces it. Because positive feedback loops are inherently unsteady, the body moves closer to crashes with the smallest trigger. Ultimately, if not resolved, the body will collapse-a return to ultimate simplicity.
The myriad of physical symptoms mentioned above is convoluted and appear confusing. However, the progression is quite logical and clear if you see them as the body's way of slowing down. Indeed, like a domino effect, the shutting down process happens in steps. At the end, the body is reduced to bed rest. Ambulatory help for daily chores are required. Fatigue is extreme with the gastric system paralyzed, heart rate irregular, mental function clearly compromised, while the feeling of wired and tired abounds, as adrenaline is high when energy is low.
This continuum of down-regulation will not stop until the body finds its equilibrium. This is the point where energy demands slow to a point that matches the input. This is the point when the body finally feels it can survive and not threatened. Sad to say many are often bedridden at this state.
Understanding the above down-regulation and return to simplicity during an adrenal crash is very important not only to explain the various symptoms that concurrently arise defying conventional medical logic. It also serves as the basis of our understanding of why certain common remedies and approaches do not work but in fact make things worse when the body is in such a state. Lastly, it serves to guide us on recovery planning.
The complete crash and recovery cycle is broken down into two phases: the Crash Phase, where the body decompensates with worsening symptoms, and the Recovery Phase, where bodily function is gradually restored to the pre-crash level of function.
The most prominent symptom during the adrenal crash phase is fatigue and lack of energy. The sum of all dysfunctional and dysregulated hormonal and metabolic pathways ultimately results in reduced energy output as the main outcome. Gauging the energy level during the crash phase therefore gives us the most accurate indication of the severity of the crash over time. There are no laboratory tests that can quantify this objectively. The more intense and more symptoms coming from the adrenal crash, the deeper and more severe the crash.
The Recovery Phase is marked by a gradual return to pre-crash level of adrenal function and energy level. Symptoms of adrenal crash will reduce and spontaneously resolve as recovery proceeds. The Recovery Phase is further broken down into a stabilization period followed by one or more mini-recovery cycle, each consisting of a preparation period, a honeymoon period, and a plateau period. The three period flow in sequence resembles a set of steps going up. The overall successful recovery plan consists of multiple "S" curves in an upward sustained series without allowing any major downward crashes. This is illustrated in the graph above and it is comprised of the following:
Stabilization Period. Immediately after an adrenal crash and prior to the initial min-recovery leg up there usually is a stabilization period where the body ceases to decompensate and gradually arrive at a steady state of lower function. As we shall see later, this stabilization period carries an important and significant role in the overall Recovery Phase. The sensation is "the worse is over, but it can come back anytime".
Preparation period. This period normally lasts from 1 day to 6 weeks, depends on the stage of Adrenal Fatigue. The stronger the adrenal function, the shorter the duration. During this time, the body normally may not feel any significant energy difference even though nutrients have been administered, though there is a sense of improved control and reduce sense of impending doom. One continues to feel fatigue, but there is a subtle sense of improvement if one pays careful attention. This is the phase where the body builds its lost reserve and internally gets stronger. It is not uncommon to feel even worse from time to time.
Honeymoon Period. This usually follows immediately after the preparation period and can last a few days to 12 weeks if the preparation period is carried out properly. Again, the duration is highly dependent on the stage of Adrenal Fatigue. Generally speaking, the earlier the Adrenal Fatigue stage, the longer this period can last. The weaker the adrenals, the more tendency for this period to be short-lived unless under professional guidance. During this time the body is able to handle stress better. Fatigue reduces, palpitation frequently dissipates, and anxiety attack diminishes. Blood pressure starts to stabilize, brain fog starts to dissipate, and functional sleep returns. There might be mini-crashes and setbacks from time to time that last a few days. They are more tolerable compared to before, but recovery is faster. There is an overall sense of well being as if a burden has been lifted from one's shoulder. An overall sense of optimism returns.
Plateau Period. The body is stabilized. There is no set time frame for the duration of this period. Generally, it lasts a few weeks to a few months. In early stages of Adrenal Fatigue, this phase can go on for years and totally asymptomatic. In later stages of Adrenal Fatigue, the picture is much more dismal. Sufferers have to slowly adapt to an overall lower level of energy function. If the adrenal function is already at its maximum, one can be stuck at this phase for a very long time without upward progress. Many on self-guided programs would not be able rise to the next cycle due to the lack of foresight and planning. This is perhaps the most trying time, as impatience sets in. Most interpret the lack of continuation and sustained improvement as failure and become disappointed. Yet within this period often is embedded a resetting time where the body can be pushed to a higher level of function if take advantage of properly.
Most Adrenal Fatigue sufferers, especially those with advance weakness, go through multiple crash and recovery cycles over time. A careful analysis and comparative study of triggers and accompanying symptoms of each cycle over time serves as a good guide on overall adrenal function.
Adrenal Fatigue sufferers are no strangers to "crashes". The crashes are usually the first alarm bell to ring early on in Adrenal Fatigue. At first they appear harmless, and can be as simple as a short period of exhaustion that recovers spontaneously after taking a nap or a sugar fix; or by way of a caffeine crash after the stimulatory effect of caffeine has worn off. With time, crashes become more intense and more prevalent. In severe cases, crashes can be triggered by something as simple as taking a longer than usual walk, and can last for months. They can vary greatly in intensity, depending on the stage of Adrenal Fatigue.
With each crash, the body usually recovers on its own. Internally, the body gets weaker with each crash. If not properly nurtured back to full function, these small crashes become more frequent, and more intense. Over time, as the body gets weaker, the recovery time also lengthens. The body enters stage 1 of Adrenal Fatigue and slowly gets worse, advancing to stage 2 and 3, and ultimately adrenal failure if no steps are taken to repair the damage.
Minor crashes can occur infrequently in the early stages of Adrenal Fatigue (stage 1 and 2), and every few days in late stage Adrenal Fatigue (stage 3 and 4). Major crashes usually only occur once every few years in early Adrenal Fatigue, but can occur as frequently as every few weeks in late stage Adrenal Fatigue such as adrenal exhaustion (stage 3). In such cases, the body never really gets a chance to fully recover. It goes through one crash cycle after another. If corrective steps are not taken to nurture the adrenals back to health, the body becomes preoccupied with fighting the crashes and trying to recover and function normally while being on the alert for the next crash. This constant state of alertness and repeated activation of the emergency system of the body to overcome crashes eventually drains the body of much needed energy, leading to a state of chronic fatigue and physical exhaustion.
In severe cases (adrenal exhaustion stage 3C or 3D or beyond), the sufferer may be bedridden in a state of what is described as "living hell" or "walking dead". On the outside they look normal. On the inside, they can hardly function. Conventional medicine's understanding of this state is unfortunately quite poor.
All adrenal crashes are precipitated by some form of stressor event, if one looks deep enough. Such events may be obvious (such as death of a loved one) or minor (such as taking a long walk). Small crashes might also delude detection. It is of paramount importance that the cause of each crash be fully investigated. The same stressor will likely trigger subsequent crashes. This is where an expert clinician's guidance is critical. History will likely repeat itself if no steps are taken understand what triggers the current crash and steps taken to prevent it from occurring again.
Examples of situational stressors that can trigger adrenal crashes include: overwork; dehydration; long road trips; vacation; dental procedures; infection, overexposure to sun, lack of sleep, sexual intercourse with ejaculation, drinking soda or coffee, medication withdrawals, especially steroids; thyroid medication sensitivity, especially T3; infection such as the flu or insect bites; overmedication such as the use of steroid and anesthesia with epinephrine, investigative procedures such as ACTH stimulation test. Other stressors trigger include: over use of stimulatory supplements, metal toxicity, excessive exercise, exposure to heat such as sauna or steam room, exposure to toxic fume, prolong standing, overly anxious, relationship difficulty, death of a loved one, long airplane or car trip, sexual intercourse especially with ejaculation, moving, overly aggressive detoxification such as enema, homeopathy, certain massages or acupuncture, excessive improper breathing and use of stimulatory breathing exercises, and excessive stimulatory entertainment such as watching an action movie or riding a roller coaster.
It is important to note that the more advanced the Adrenal Fatigue, the less intensity the stressor needs to be to trigger an adrenal crash. The body's reserve in advanced Adrenal Fatigue is already low and very close to hovering above the adrenal symptom threshold level. It does not take much to cross this threshold as the crash occurs.
Not all adrenal crashes and recovery cycles are symptomatic. Those with stage 1 and early stage 2 Adrenal Fatigues may not even be aware, especially if there are sufficient adrenal reserves at hand to compensate and ensure normal daily function. On the other hand, symptoms are universally present for those in stage 3 and 4 Adrenal Fatigue when they crash, and their symptoms vary greatly in severity.
Symptoms of adrenal crash represent a sudden intensification or abrupt onset of the many already existing pre-crash Adrenal Fatigue symptoms, such as:
You need not have all of these symptoms to have an adrenal crash. Sometimes, you only have a few of them, but they are usually severe. Sometimes the degree of decompensation can be quite mild and minor. Other times, they can be severe and major. Generally speaking, the more intense the symptoms, the more severe is the crash. Crash intensity can be classified into five levels which will be explained later. One can experience any degree of adrenal crash at any stage of Adrenal Fatigue.
Clinically, Adrenal Fatigue Crashes are classified into 5 levels based on subjective evaluation. Levels 1 and 2 are considered minor crashes with good recovery potential, while levels 3, 4, and 5 are considered major crashes and have a much less certain Recovery Phase.
Level 1 - loss of 10-19% of immediate pre-crash baseline level of adrenal function in terms of energy, metabolic imbalance such as hypoglycemia, and emotional function such as irritability. Typically, there is a sense of being more tired than usual, more irritable, and a sense of being hungry earlier than normal. Normal outside work, as well as household chores, can be completed, though a sense of tiredness is felt at the end of the day. A nap can be extremely helpful and the sense of recovery is felt after rest.
Level 2 - loss of 20-29% of immediate pre-crash baseline level of function in terms of energy, metabolic imbalance such as hypoglycemia, and emotional function such as irritability. Typically, there is a definite reduction in energy, but that can be compensated practically by a nap or lying down for 30 minutes. Emotional stability is less and easily irritated. When it is time to eat, there is a sense of relief. The ability to perform normal outside activities such as a job or regular household chores is compromised but can be forced to be completed if needed to. Even with a nap and rest during the day, the body is tired and not quite the same. The body is under strain.
Level 3 - loss of 30-39% of immediate pre-crash baseline level of function in terms of energy, metabolic imbalance such as hypoglycemia, and emotional function such as irritability. Typically, the energy level is low throughout the day. Even with rest and a nap, the body remains very tired. There is moderate reduction in the ability to perform all outside activities as well as household chores. One feels like staying home all day and not just for a few hours to rest. Anger, short tempered, and rage is common. The body craves sugar for energy at times. Insomnia is worse, and in many cases, accompanied with cold sweats, heart palpitations and dizziness.
Level 4 - loss of 40-49% of immediate pre-crash baseline level of function in terms of energy, metabolic imbalance such as hypoglycemia, and emotional function such as irritability. Typically, there is severe fatigue throughout the day. Unable to do most household chores, and the body feels totally drained. Emotionally depressed and too weak emotionally to get angry. Food or supplements that generates energy before may make things worse. Unable to get to do outside chores is a key characteristic. Those who are working will be unable to go to work. Even sounds from the TV can be irritating. Once in bed, it's hard to get up other than to go to the kitchen to prepare food.
Level 5 - loss of greater than 50% of immediate pre-crash baseline level of function in terms of energy, metabolic imbalance such as hypoglycemia, and emotional function such as irritability. Bedridden most of the time, getting up only to accomplish the basic personal hygiene chores. It's not unusual to require assistance for ambulation or taking a shower or changing clothes.
One can have any number of minor or major crashes during any stage of Adrenal Fatigue.
The following diagram shows the typical general progression of Adrenal Fatigue over time, with steady deterioration during Stage 1 and 2 that is generally asymptomatic. This is followed by a rapid and functional decline in Stage 3 which is especially severe in Stage 3C. If unattended, the natural progression ends in adrenal failure. The exact progression varies from person to person with wide variations.
There are many crashes and recovery during along the way. Let us start to examine more closely the natural of these crashes in each stage.
In this stage, the body is alarmed by the stressors and mounts an aggressive anti-stress response to reduce stress levels. Some doctors called this the Early Fatigue stage. Unfortunately, this sub-clinical state is seldom recognized as a pathological condition. Blood sugar levels become imbalanced, resulting in low energy. This dysfunction is temporarily patched by the intake of quick fixes such as high sugar content soda drinks, energy potions, and high carbohydrate foods such as donuts. Many people even consider this state "normal" as part of living in the modern society under stress. Those who require coffee to start the day may already be in this stage and not be aware of it.
Crashes in this stage is usually minor (Level 1 or 2), though a major crash (Level 3 or higher) may occur once every few months and a major crash every few years. No physical symptoms before, during, or after the crash other than mild discomfort are reported because symptoms at its worse are still above the Adrenal Symptoms Threshold (AST). If a major crash occurs, recovery usually takes a few days or weeks at most and full recovery is achieved. Crashes in this stage usually go unnoticed and is only evident on retrospect.
With chronic or severe stress, the adrenals eventually become unable to compensate. Normal daily functions are still able to be carried out, but the sense of fatigue is pronounced at the end of each day as the body needs more rest than usual to recover. Despite a full nights rest, the body often does not feel refreshed in the morning. Anxiety starts to set in, and the person becomes easily irritable. Insomnia becomes more common, as it takes longer to fall asleep. There are also frequent awakenings as well. Infections become more recurrent. PMS and menstrual irregularities surface, and symptoms suggestive of hypothyroidism (such as a sensation of feeling cold and a sluggish metabolism) become prevalent. The thyroid glands are usually affected at this stage. Sluggishness, feeling cold, and central weight gain, despite exercise and diet, are the predominant symptoms that usually bring patients to their physicians for the first time. Many are prescribed anti-depressants and told there is nothing wrong physically. Those who require multiple cups of coffee to sustain themselves may well be entrenched at this stage without knowing it.
Compared to stage 1, the frequency of minor and major adrenal crashes is higher. The intensity is also increased. AST has been penetrated on the downside. A mild degree of adrenal symptoms are usually present before the crash, but not always. During the adrenal crash, these symptoms are made worse and exaggerated, but still manageable. Many recover fully with no symptoms after the crash as they rise above the AST, but not all are so fortunate. A significant number remains symptomatic below the AST after recovery with symptoms that are slightly worse than the state they were in pre-crash. These crashes are often what brings the sufferers to their physicians for the first time.
In the figure below, we see a graph covering stage 1 and 2 Adrenal Fatigue and the progression of each crash and recovery cycle. The adrenal function is plotted against time. Note at some point in adrenal function, a level comes into play where the sufferer goes from asymptomatic (no symptoms) to symptomatic. This is the called the Adrenal Symptoms Threshold (AST). Crashes that occur above this threshold are generally asymptomatic. They are generally unnoticeable unless the sufferer is attuned to his own body condition. In stage 1 Adrenal Fatigue, a crash is generally followed by an immediate recovery, both of which occur above the Adrenal Symptoms Threshold (AST). At most, there may be a brief period of exhaustion. A total recovery is expected with a short nap or drinking coffee.
With each crash, the remaining adrenal function is reduced slightly after recovery. The more crashes occur over time, the weaker the adrenal function becomes. Fortunately for those in this stage, there is adequate adrenal reserve as the AST has yet to be penetrated on the downside. As a result, Adrenal Fatigue as a trigger or cause is frequently overlooked. This can go on for years and decades.
Crashes associated with stage 2 Adrenal Fatigue are characterized by a higher intensity of symptoms compared to crashes associated with stage 1. The pre-crash energy level is lower than stage 1 Adrenal Fatigue at the baseline to start. At the height of the crash, the adrenal function usually descends and penetrates the AST. Physical debilitating symptoms start to appear, including high blood pressure, insomnia and low blood sugar. As with crashes associated with stage 1 Adrenal Fatigue, each crash and recovery cycle end at an adrenal function status that is slightly compromised compared to before. This is a gentle downward cascade of functions resembling a waterfall or a series of steps going down. The duration of the Recovery Phase is at least 2 times or more longer when compared to that experienced in stage 1 Adrenal Fatigue.
As the body enters Adrenal Exhaustion (stage 3), the clinical picture changes drastically for the worse. In this phase, mild symptoms characteristic of first and second stage Adrenal Fatigue continue to worsen and become persistent or chronic. Just to mention a few symptoms: the slightly elevated blood pressure now becomes low throughout the day, mild musculoskeletal pain turns into chronic fibromyalgia around the clock, frequent recurrent infections are the norm in comparison to intermittent infections, occasional mental feeling of "blues" becomes mild depression, sleep patterns become more disrupted as insomnia becomes chronic, and fatigue that usually occurs during the end of occasional stressful days becomes an everyday event. There is a moderate reduction in carrying out normal daily activities. Most people are exhausted after a full day's work. Not all organs are dysfunctional to the same degree at the same time. The organ system that is constitutionally weakest is the first one to decompensate, while another organ system appears to be intact.
Minor crashes are becoming increasingly common, occurring once every few weeks. Major crashes usually occur once every 6 to 12 months. Symptoms are prevalent pre-crash, and because most are long-standing, the sufferer has adapted to them with their daily life function at a lower energy baseline level. During the adrenal crash, the symptoms worsen. Even after recovery, the body remains in symptomatic state below the AST most of the time.
The endocrine system in our body is linked hormonally in a series of axis for optimal function. Dysfunction in one system invariably affects the others, leading to a cascade of decompensation as the body weakens. In this phase, the ovarian-adrenal-thyroid axis in women and adrenal-thyroid axis in men are particularly compromised. When these axis become imbalanced, the adverse feedback loop creates a vicious cycle of cascading decompensations, involving multiple organ systems at the same time. Typical presentations in the female involve symptoms of under-active thyroid, imbalanced ovarian hormones, and low adrenal function. In the male, the adrenal-thyroid axis may be compromised. Sufferer's physical and emotional states continue to deteriorate and they enter into a state of confusion in this phase. They are unable to logically dissect the myriad of systematic manifestations of multiple hormonal axis imbalances.
Compared to those experiences in stage 3A Adrenal Fatigue, crashes are usually more intense and more frequent as the adrenal reserve is depleted. It is not uncommon to have minor crashes every 1-2 weeks, and major adrenal crashes every few months. The body never fully recovers to a point that the energy is consistently above the AST at any point in the crash and recovery cycle.
As the body continues its downward path of impaired functions, it gathers steam. Gradually, the body becomes severely compromised in trying to maintain the fine controls of homeostasis. Normal equilibrium is therefore lost. The body will try its hardest to maintain equilibrium; but its crude compensatory response, damaged receptor sites, along with impaired metabolic and detoxification pathways of a low clearance state, give rise to paradoxical and exaggerated responses. This is usually mediated through the autonomic nervous system. Clinical manifestations include swings in blood sugar level, with reactive hypoglycemia being the hallmark, along with fragile blood pressure state, postural hypotension, inability to remain standing for a prolonged period of time, reactive sympathoadrenal responses including heart palpitations, night sweats, and a state of reactively driven anxiety followed by depression. Normal ambulatory and functioning time is usually very much restricted.
Crashes that occur in this phase are fast and furious. Minor adrenal crashes can occur every few days, and major ones as often as every few weeks. There is a roller coaster ride of ever worsening symptoms. It is not unusual for one to go from minor crash immediately into a major crash before the minor crash has even completed its recovery. There is a state of constant fatigue, with severe energy depletion. The highest rate functional decline occurs at this phase. A major crash can be very scary, and may require trips to the Emergency Room.
As the body's cortisol hormone level falls below the minimum required reserve for normal function and output fails, the body continues to down-regulate the amount needed in order to preserve what is on hand for only the most essential body functions. Pump-failure occurs. This down-regulation further reduces cortisol output, exaggerating a vicious downward cycle. Toleration to steroids may be blunted or negated. Normal nutrients are often systemically rejected by the body, even at low doses.
Those who are in this stage often live in the hopeless state of constant crashes. The body is too drained to mount a productive response. Adrenal crash symptoms are usually extreme. Minor crashes can be intermingled with major crashes. Emergency room visits are common due to unstable blood pressure, irregular heart rate, and severe anxiety with a sense of impending doom. Sufferer is usually bedridden requiring assistance for daily chores and personal hygiene functions.
The following figure shows how the same process works in those with Adrenal Fatigue stage 3A to 3D Adrenal Exhaustion. In this stage, the intensity of body crash continues to increase, despite a crash time that may or may not be much longer than that of earlier stages. However, clinical observation shows that the Recovery Phase is exponentially longer. Recovery Phase for stage 3C crashes can be 20 times or more, longer than that of stage 1.
In addition to longer recovery time, sufferers remain symptomatic below the AST throughout almost the entire crash and the recovery experience. Those in Adrenal Exhaustion have a very low adrenal pre-crash reserve at baseline. Their pre-crash adrenal function is hovering slightly above the adrenal symptoms threshold during the best of times. It does not take much external stressors to push the adrenal function lower and cross the threshold into the symptomatic area. Compared to earlier stages, stress triggers can simply be something that would not have triggered a crash in early stages. This may be a longer than usual walk or inadequate fluid intake. The body is much more sensitive to stressors as adrenal weakness progresses.
The following summarizes crash symptoms clinically:
|Adrenal Fatigue Stage||Interval Between Level 1 and 2 Crashes||Interval Between Level 3,4,5 Crashes||% Symptomatic Pre-crash||% Symptomatic During Crash||% Symptomatic During Recovery||% Symptomatic Post Recovery||Degree of Adrenal Crash Symptoms|
The key to managing an adrenal crash is to reduce the crash velocity, lessen the intensity, and administer proper nutrients at the right time to propel the system into recovery as soon as possible.
Minor adrenal crashes (loss of 10 percent to 29 percent of energy) usually go unnoticed in Stage 1 and 2 of Adrenal Fatigue. All crashes are noticeable in Stage 3 and 4 of Adrenal Fatigue. Major crashes involving a loss of 30 percent or more of energy can be devastating at any stage.
The more advanced the Adrenal Fatigue, the less reserve is present in the body, and therefore, the faster the crash. The same stressor that takes a few days to trigger a crash in those with Stage 1 and 2 Adrenal Fatigue may only take a few hours to cause the same damage in those with Stage 3 and 4 Adrenal Fatigue. Crash intensity is also greatly magnified in terms of symptomatology-the weaker the adrenals, the cruder the way the emergency systems are activated.
Proper crash management requires individualized attention. Everyone is different, and there are no standardized protocols. What may be fitting for one person may actually make another person worse. The following are key areas to be addressed during crash management:
Due to the inherent complexity, management is best left to the experienced clinician. Even then, some trial and error is expected due to poorly understood underlying physiology.
While an adrenal crash is one of the most dreaded and difficult period to manage in Adrenal Fatigue, there is often a silver lining.
During a crash, the body first goes through a series of adaptation to return to homeostasis. When this fails, various internal emergency systems are activated automatically. The more intense the crash, the more the response becomes evident and exaggerated. As a result, unpleasant and paradoxical symptoms are made worse, this results in a worsening downward cascade of fatigue as the crash progresses. At peak of the crash, the energy may be so low that one may be bedridden. Eventually, the body usually is able to regain internal control, except for those who have very weak constitutions. It then enters a stabilization period, to be followed by a preparation period before the body starts its honeymoon period of recovery. This is graphically shown as Curve A in the diagram below.
During the crash, the body is actually hungry for more nutrients to overcome stress. Much of the internal reserve is utilized and metabolized in its effort to soften the crash. Nutrients needs to be replenished as quickly as possible once utilized. Additional nutrients may be considered to support the body during this process. Unfortunately, the body is concurrently in a low clearance state during Adrenal Fatigue. In its best effort to conserve energy, many organ systems are put on a "slow down" mode of function. Gastric absorption is slowed and liver detoxification rate is reduced. As excretory capacity is compromised, breakdown byproducts accumulate within the body and turn toxic. Symptoms such as brain fog, joint pain, muscle ache, etc are common as a result, making the crash worse or triggering subsequent rolling crashes. Extra nutrients administered during this time of low clearance state can lead to a variety of toxic and paradoxical reactions. Instead of getting better, the crash worsens. This is graphically shown as Curve D in the following diagram:
Those in a low clearance state should therefore temporarily avoid additional nutrients during an adrenal crash. Nutrients should be titrated downwards to allow the body to first clear existing metabolites out of the system in order for the body to stabilize as shown in Curve A in the diagram above. Aggressive detoxification such as enema, cleanses, massages and acupuncture should also be avoided unless under professional guidance, as they can worsen the condition as more toxins are released, leading to a re-toxification reaction. This is shown as Curve D in the diagram above.
Those with a stable or normal clearance states, on the other hand, can tolerate more nutrients during or after a crash. Additional nutrients can be of great help to cushion the crash intensity, reducing unpleasant and paradoxical reactions as well as affecting an overall faster entry to the recovery phase during the crash (Curve B in above diagram) or at the peak of the crash (Curve C in above diagram). With proper timing and dosage, these nutrients can have significant benefits. Not only is the crash intensity reduced, but the body can be propelled into the honeymoon period of the recovery phase directly from the crash phase, resulting in an earlier recovery. The stabilization and preparation period can be bypassed. One can go directly from crash to honeymoon, as shown in Curve B and C in the above diagram.
Clearly, determining the clearance state is an important parameter in any adrenal crash management program. Unfortunately, there is no laboratory test available in determining the clearance state and thus no automated program to facilitate the recovery process. However, an experienced clinician is usually able to determine the clearance state based on a detailed medical and nutrient reaction history. Seeking the proper qualified specialist is therefore critical for those who frequently experience crashes.
Once a crash has occurred, one of the most difficult questions to answer is the length of crash and its subsequent recovery period. Sometimes, one can crash and recover within a few hours. On the other end of the spectrum, the complete cycle can take a few months. There is no quantitative measurement that can precisely calculate or predict cycle duration. The best estimate comes from a combination of past history, clinician's experience, and the state of adrenal function immediately prior to the crash (also called baseline).
Let us examine how Adrenal Fatigue staging at baseline correlates with cycle duration. The following figure represents a graph of the average speed of crash and recovery as it relates to various stages of AF.
The more advanced the Adrenal Fatigue, the faster and the more intense is the Crash Phase. In other words, those in Stage 3C or 3D Adrenal Fatigue crash much faster and with deeper intensity compared to those in stages 1 and 2.
The Recovery Phase characteristic and duration also varies greatly depending on the state of adrenal function immediately pre-crash (baseline). Recovery for those with Adrenal Fatigue stage 1 tends to occur quickly. As adrenal weakness increases, the duration of Recovery Phase increases exponentially. In other words, stage 2 recovery may be doubled that of stage 1, and stage 3A many times that of stage 2. Those in stage 3C or 3D may need recovery time as much as 30 times or more longer than those in stage 1 for the same level of crash intensity.
The adrenals, even after recovery, are generally weaker with each crash, regardless of the stage. The degree of weakness may not be significant to the sufferer in stage 1 or 2, but can generally be detected if careful attention is paid to the details of daily function. The signs, symptoms, intensity, and the nature of stressors are subjective in nature. What is considered intense for one person may not be for another. Many factors are involved, in addition to each body being different. Descriptions of crashes are therefore qualitative and not quantitative in nature. There is no precise way to accurately mathematically standardize each crash over a large and statistically significant sample base. Thus, forecasting total cycle time based on crash intensity is at best a clinical guesstimate and not an exact science. Adrenal Fatigue sufferers have a tendency to expect faster recovery time than usual because they are used to the same level of stressors producing a shorter cycle in the past. This expectation is often unrealistic. The understanding of this is critical to properly managing recovery expectations as well as the design of a comprehensive program because proper time needs to be allotted for the body to heal itself. It is not realistic to expect a stage 3C sufferer to have the short Recovery Phase of one that has stage 2 Adrenal Fatigue unless the former is under expert care. The dosage of nutrients used in stage 3C recovery is therefore necessarily different. One of the most common recovery mistakes is the over-administration of nutrients in those with advanced Adrenal Fatigue especially during crashes. This often leads to failed recovery and repeated crashes in a downward cascade resembling a waterfall. A good clinician with extensive experience is the key to navigate through adrenal crashes. A trial and error approach common of most self-navigation programs through this unchartered water can do more damage than good to the body.
By understanding this progression, we will be able to properly manage and match nutritional recommendations to the body's physiological progression and needs.
The Recovery Phase covers the time from the peak of the crash when the energy is lowest until such time the body returns to its immediate pre-crash level of adrenal function and energy level. Contrary to the crash phase, the Recovery Phase is harder to detect with clarity. Sometimes recovery is fast, but often it can be slow and laden with frequent setbacks. The more advanced the Adrenal Fatigue, the less possibility of a 100% recovery.
Under ideal or professionally managed conditions, the Recovery Phase is marked by multiple mini-cycles each consisting of three components: preparation, honeymoon, and plateau. Each mini-cycle can range from a few days to a few weeks. The weaker the adrenals, the more such mini-cycles are needed and the longer each mini-cycle will last to return to pre-crash level of function. Such mini-cycle may also be a set-up for follow-up rolling crashes if not handled properly.
The successful recovery's post-recovery energy is generally still below the level of pre-crash levels in most situations. It is not uncommon to have a second or third dip or setbacks during the entire recovery process. For some, there is a prolonged period of stabilization before the first recovery mini-cycle begins. This is very common especially in those with Adrenal Fatigue stage 3 or beyond. On the extreme, some do not recover at all but instead progress to the next crash after a period of stabilization.
Over time, however, one can usually detect a definite Recovery Phase following each major crash phase if one pays careful attention to the swings. Compare to an easy-to-track-down leg of the adrenal crash, the recovery curve can be flat with only minor improvements. The more severe the adrenal crash and the weaker the adrenals, the more difficult it is to spot this. The following figure shows the various recovery curves possible.
Curve A represents a normal recovery with many mini-recovery cycles along with inevitable setbacks, but a gradual up trend in adrenal function.
Curve B represents an accelerated recovery occurring usually in those with early stages Adrenal Fatigue (stage 1 and 2), or those with very strong constitution. This curve is also associated with those who are able to go from the crash phase to honeymoon period directly, usually under professional guidance. This is the most desirable curve.
Curve C represents a prolonged stabilization period and delayed recovery common in those with Adrenal Exhaustion (stage 3)
Curve D presents a failed recovery after a moderate stabilization period with progression to a subsequent adrenal crash common in those with weak constitution and adrenal exhaustion. This is the least desirable.
All four types of recovery curve are possible in any stage of Adrenal Fatigue, though the delayed and failed curve is more prominent in the more advanced stages of adrenal weakness as well as those with weak constitution.
Stage 1 and 2 Adrenal Fatigue as well as those under optimized recovery programs are frequently associated with recovery curves resembling curves A and B, regardless of constitution. Stage 3, stage 4, weak constitution, and self-guided recovery programs are more associated with curves C and D. It is extremely rare for an Adrenal Fatigue stage 3 to exhibit recovery following that of curves B unless under proper guidance. In fact, the natural progression for stage 3 Adrenal Fatigue is slow decompensation, following curve D if nothing is done or if over-zealous programs are administered by inexperienced hands. Those with a strong constitution and professionally managed are the ones with the highest likelihood to achieve a recovery curve similar to curve B.
Unless the adrenal glands are given the proper tools and nurtured back to health naturally (preferably professionally), most recoveries are eventually followed by subsequent worsening crashes as the natural progression of this condition.
Signs of adrenal recovery are usually less prominent and more insidious. They include:
It is important to note that stabilization is part of the recovery process as mentioned above. In other words, if the symptoms of crash are not worsening, the body is likely in the transition from crash to recovery and in stabilization portion of the Recovery Phase.
The main focus of recovery is quite different from that of an adrenal crash because the total recovery process is usually complicated and drawn out. While the adrenal crash phase usually takes a few hours to a few days to complete its course, the complete recovery phase can take weeks and sometimes months. Those with weak constitutions are especially vulnerable to an overall delayed recovery phase. The main focus of adrenal crash management is to reduce crash intensity and duration. An analogy would be like quickly assembling a safety net to catch a falling person in order to soften the harsh landing. The main focus of recovery management is to provide the body with enough tools for it to heal itself even though it might take a long time. Adrenal recovery management is like leading a blind man across a stream. The motto is to go slowly and gently, one foot at a time. One foot is always ahead trying to feel where and how secure the next rock is before actually put the body weight on it. That is how one avoids falling into the water, or in the case of adrenal recovery, crashing.
Think of the recovery process as running a long distance race instead of a sprint. You need first to be strong enough to get up, start, and finish the race. That requires systematic planning, training, and budget for setbacks. At first you may only be able to finish by walking. Slowly you improve and start working out the speed. Most successful running programs stress a gradual and systematic approach, with intermittent challenge runs along the way as a gauge of your body's reserve and energy level.
The body is not a light switch that can be turned on and off at will. Adrenal Fatigue that takes years to develop should be given ample time to heal itself. A common mistake in recovery management is to focus on a speedy recovery, which sacrifices the more important concept of rebuilding the underlying reserve. Pushing the body ahead of its readiness is a recipe for crashes and ultimately recovery failure.
A successful recovery management program incorporates the following factors:
Failure to consider all the above factors is a common reason why most recovery programs fail. Recovery management must be taken seriously if the goal is full recovery. What is commonly forgotten is that Adrenal Fatigue, if left to itself, progresses negatively with aging. Invariably, crashes will resurface again with time, and fatigue will advance if the previous healing process is incomplete. Those who tend to ignore the importance of recovery management during early stages usually become overly confident in self-management from previous successful efforts. This is compounded by the fact that the majority of conventional physicians are of little help. The tendency is then to continue to self-navigate using the same concept that worked before. This usually involves rest, use of stimulatory compounds, and medications to suppress symptoms. Sad to say that this strategy often backfires in those with advanced Adrenal Fatigue.
Proper recovery management is far more complicated than what meets the eye, especially for those in advance Adrenal Fatigue. The weaker the adrenal function, the more critical proper recovery management becomes. Patience is also required as many challenges, trials and errors are inevitable even in the best of hands. During a crash, the proper type of food and nutrients ingested becomes critical. Let us take a closer look.
A body in severe down-regulation during adrenal crash is only interested in basic energy input that it can use effectively without expending a lot of energy to get it. It will simply reject everything else. Since energy comes from food, this means that the food we take in must be easy to digest, assimilate, bought into the cell, and convert into energy quickly without a lot of energy expenditure. Think of an infant. For the first few months after birth, an infant's full nutritional needs can be met by taking in mother's milk alone. That is all baby requires at that point when the gastric intestinal tract has yet to be fully developed. Months later, food can slowly be introduced, one step at a time. This gradual process delivers nutrients to the system that matches the body's digestive apparatus maturation. Any attempt to give solid or whole food, or even worse, processed food, to a baby too soon will lead to vomiting and indigestion. The body will reject food, even though it is nutritious, if it is before its time.
In advanced Adrenal Fatigue or during adrenal crashes, the body is returning to a simple state. The weaker the adrenals, the less the body is able to tolerate complex and processed foods as it simply does not have the energy to divest to break down these complex foods. Wheat, gluten, and dairy products are particularly problematic as these are more difficult to digest. Increasing bowl irritation (with symptoms such as constipation or diarrhea), bloating, delayed food sensitivity, and gas are signs that the gastro intestinal tract is compromised and the body taxed. Vomiting may ensue if we continue to ignore the body's signals asking us to simplify our food or reduce the quantity. Those with advanced Adrenal Fatigue therefore will often find it necessary to reduce the complexity of food intake. They may have to be pureed to be absorbed.
Those with extreme Adrenal Fatigue need nutrition at the most basic level-rich in nutrient and easy to digest. This means food usually in liquid form. These include raw colostrum, raw milk, raw egg, chicken broth, and rice porridge. The amount needs adjustment to match the body's ability to absorb. Some can only take a few teaspoons at a time and need significant rest in between.
As the body returns to simplicity during a crash, nutritional supplementation considerations also need adjustment to the most basic kinds and those that are most bioavailable at the cellular level. Complex nutrients are of little use when the body is unable to break it down into proper components for proper absorption and cellular delivery. One must avoid nutritional supplements that are complex, including certain herbs. Glandular can also be problematic due to intrinsic low clearance of the body that usually comes with advance adrenal weakness.
The volume of supplements also requires adjustment. Over-supplementation is a common mistake. Many advanced Adrenal Fatigue sufferers are taking a basket of nutritional supplements to sustain their energy level. This approach is risky. Unless properly titrated, unmonitored intake of complex or stimulatory compounds to enhance energy flow usually ends badly. This becomes worse when a nutrient that has a positive effect early on can turn negative as Adrenal Fatigue worsens. This accounts for the many paradoxical reactions we see.
All supplements must be carefully selected. Nutrients not properly matched to the body's requirement at any stage are a sure recipe for failure. After reaching maximum stimulatory levels, it is usually only a matter of time before the body crashes. Supplements, no matter how beneficial, are only as good as the body's ability to absorb and process. A weak body has limited energy to digest nutrient and thus is not able to garner the beneficial effect of the supplement as a result of poor absorption. Furthermore, energy used to digest supplements can further drain the body of its already low reserve if too many supplements are taken in a day. More nutrients at a time when the body is crashing or down-regulating are therefore not necessarily better. It may have worked before when the body's reserves were large. In a weak body heading towards simplicity, this strategy can backfire. A personalized nutrient program is necessary, using only a few nutrients most needed by the body. These have to be absorbed through the gastro-intestinal tract in a most energy neutral manner, and made bio-available to each cell in the most efficient manner.
Understanding the concept of having nutrient type and dosage match the body's need in every stage is key before one can plan a proper recovery program. Knowing the body's unique nutrient history is, therefore, a critical component in tailoring the right dose and the proper delivery system to affect maximum healing.
Only the most basic nutrient most needed by the body should be used when the body is vulnerable. Undesirable supplements should be terminated gradually. Abrupt cessation should be avoided and care must be taken to avoid any rebound or withdrawal effect.
In addition to selecting the right supplement, micronutrient delivery to the cell is also a key factor. Tablets need restraint, due to high content of binders and fillers. Powder high in sugar is likewise something to avoid. Liquids are best, but only if the proper delivery system is employed. Use various forms of the same nutrients to affect maximum bioavailability because each form has its own unique characteristic in terms of potency, half-life, absorption, and breakdown curve. A custom blend and mixture using various forms can have potent synergistic effects well above any single form of the nutrient.
The take home lesson is that nutrient is only good when it matches the body's ability to absorb. A normal body has plenty of reserve to take in complex and processed food without difficulty. The Adrenal Fatigue body is very different. It is a body trying to return to simplicity. This requires simple food and simple nutrients delivered properly for maximum benefit.
Fortunately, if one takes proper action using natural compounds and proper nutrition the adrenal crash is not permanent. The body possesses self-healing powers if the right tools are available. Over time, a weak adrenal can strengthen. As this happen, fatigue subsides and energy returns. Adrenal Fatigue is therefore reversible, and recovery possible. As the Adrenal Fatigue heals and health improves, other foods can once again be ingested, normal stress tolerated, and normal life activities can resume.
Having looked at the entire recovery management process as a whole, we now turn to specific areas where special attention is required.
Many are discouraged when there is no immediate restoration of energy level after a crash and become impatient. Many equate adrenal function to energy level. Many feel, after a short time, that they are simply going nowhere and "treading water" as if there were no continuous increase in energy level. This time is commonly referred to as the stabilization period if it follows a crash, and plateau period if it immediately follows a recovery cycle.
Remember that the adrenals secrete over 50 different hormones that affect all parts of the body. Some hormones act quickly, while others take some time. Energy is important, but is not the only parameter of recovery. Those who are impatient or narrow-minded often resort to the use of stimulatory compounds or medications to produce a faster energy response. This approach is dangerous and has a higher chance of backfiring down the road. Energy needs to be properly modulated to be able to work harmoniously with the rest of the body and work. Too much energy without proper counter-balances will eventually lead to an overall weaker state of adrenal function. One can end up being energized (wired) and tired at the same time, a classic characteristic of advance Adrenal Exhaustion. A critical part of proper adrenal recovery is nurturing the adrenals back to a balanced state of function in order to minimize subsequent crashes during this time.
After a major crash, the body often needs a period of stabilization prior to beginning the first recovery mini-cycle up. This first leg up is the most difficult because the body is weakest at this time. An aggressive approach to stimulate the adrenals towards a fast recovery at this time can backfire and is one of the common recovery mistakes seen in self-navigation programs. The body needs time to regroup and reset itself. This may take weeks in those with advance Adrenal Fatigue (Stage 3 and 4). Pushing the body when it is not ready is a recipe for failure.
Allowing the body time to stabilize and using this time wisely to prepare the body with gentle nurturing nutrients is a sign of clinical excellence. With this approach, a strong foundation is set as the adrenal reserve is being rebuilt. This ensures a steady recovery and minimizes the risk of subsequent crashes during the recovery process. Minor crashes may be unavoidable even under the best of hands, especially if the adrenals are constitutionally weak. Some of the subtle indications of an adrenal being rebuilt during the initial stabilization period are a gentle and gradual return of calmness to everyday life, a better ability to deal with stress, and reduced anxiety when stressors resurface. However on the surface, there may not be any significant improvement in energy level from day to day. Fatigue continues to be troublesome. Yet, one can look back and notice that crashes are more spaced out and sporadic, with less energy depletion when that happens, and there exists a sense of calmness even when stressors surface. For this reason, a well-utilized stabilization period is the most important part of the overall Recovery Phase.
The worse recovery scenario possible is when someone recovers quickly only to be followed by more crashes that spiral down over time. This cascading waterfall must be avoided at all costs as it weakens the body with reduced chances of successful recovery with each crash. The risk of this can be minimized only if the adrenals have a chance to rebuild itself slowly and steadily under proper guidance, and the best time to successfully accomplish this is during the initial stabilization period of the Recovery Phase and the subsequent plateau period of each mini-recovery cycle.
After each mini-recovery cycle up, there is a plateau period as well. This is similar to the stabilization period; except that it only happens after the honeymoon period and not after an adrenal crash. Allowing the body to rest during the plateau is important. After rest and consolidation of energy at this level, the body will be ready for the preparation period to get ready for the next honeymoon period of adrenal recovery. Not allowing the body to go through a plateau phase by pushing the body with undue exertion, stress, aggressive medications and nutritional supplements will often increase the risk of subsequent crashes.
Often times during the Recovery Phase, the body may go through a period where it tries to reset and kick-start itself for reasons that are not well understood. Perhaps it is nature's last resort of trying to help itself when all else fails. During a crash, the body often goes into an emergency mode. This resetting may be part of the delayed survival mechanism that is activated automatically. The timing of this resetting varies from person to person if it does occur. During the resetting, the body suddenly behaves differently for no apparent reason. For example, certain nutrients that have been helpful before may suddenly be rejected. Nutrients may also have a sudden positive exaggerated response only to be followed by a negative response. This is a turbulent time for the body where most sufferers are discouraged and do not understand what to do next. The resetting state usually occurs sometime during the late initial stabilization period, late in plateau period, or sometime during the preparation period during subsequent mini-recovery cycles.
Few pay attention to, or are on alert for, this event when it happens. Even fewer are attuned to the significance of this minor but important phenomenon that is clinically evident but seldom mentioned in any literature. This event may represent an opportunity to "kick-start" the system and bring it to a higher level of function. When properly taken advantage of, this "kick-start" process can propel the adrenals into the honeymoon period. Without taking advantage and using this to "kick-start" the system during the resetting state, one can stay stagnant in the preparation period for an extended period of time due to lack of impetus. This process is made possible by taking advantage of the natural body's recovery rhythm. The body appears to be telling us to stand aside and leave it alone during this resetting state. Most make the mistake of ignoring the body's signal. Instead of pushing more nutrients at a time when the body does not welcome them, it might be better to take a pause. Learning to listen to the body is often a wiser choice. After a pause to reset body, the same nutrients may be restarted and the body welcomes them with dramatic improvement. An astute clinician attuned to this will likely catch it as he or she is on constant alert waiting for this. Recognizing such a window of opportunity and taking the right action at the right time will greatly facilitate the body's progression to the honeymoon period that otherwise would elude the sufferer. This is a sign of clinical excellence. Those who do not recognize this or miss this window of opportunity may have delayed recovery, or inadvertently make the condition worse by over-administering nutrients at a time when the body does not react well to them. A common mistake is to assume that nutrients are "not working" as fatigue levels seems to be getting worse, and that more is needed since those nutrients have worked previously.
Quantitative challenges are routinely used in modern medicine to help the physician understand the functional level of a given organ system. The most common is the cardiac stress test for those who have chest pain. A person is placed on a treadmill to run while a machine measures cardiac function. By challenging the heart to work and observing its response, physicians are able to deduce the health of the heart and blockage of heart vessels. Endocrinologists routinely use ACTH challenge tests to assess adrenal function. Tilt-table tests are used to help diagnose those with dysautonomia. In the early days, these tests were all qualitative in nature. Thanks to extensive research, standardization and quantifiable results have become the norm, and with that, standardized protocols have become a reality. Unfortunately, such quantitative tests are not available when it comes to Adrenal Fatigue. We resort to using qualitative challenges, which is less sophisticated and more subjective, but nevertheless still valuable.
Qualitative challenges are subjective assessments tools designed to assess specific functional statuses of the body's internal systems. Results are based on the subject's personal experience rather than a quantifiable numeric number. These challenges are used to give the clinician a better sense of the body's internal function with the lack of accurate, sensitive and clinically well-correlated laboratory studies. Because of its subjective nature, there is a high potential for bias and inaccuracies.
A qualitative challenge used in Adrenal Fatigue commonly involves purposely-designed adjustments of nutrients such as vitamins and minerals, dietary components such as protein and carbohydrates; exercise such as aerobics or weights; lifestyle factors such as sleep habits are used to test the body's response, both positively and negatively. For example, a sodium challenge involves taking a measured bolus of salt rather than just salting food more. Its purpose is not to quench the existing salt craving only. The body's response to the sodium challenge indirectly tells us the status of fluid and electrolyte balance. Because sodium regulation is tied to the hormone aldosterone, the body's response to the sodium challenge gives us a good idea of its aldosterone function. Since aldosterone is a hormone made in the adrenal glands, we also have a better sense of adrenal function. This is therefore a rough and indirect way of assessing adrenal function. In academic medicine, this may be considered crude and unsophisticated. However, this method is a great and simple tool for analyzing Adrenal Fatigue. Sometimes, simple challenges can sometimes yield far better insight than any laboratory test.
Positive as well as negative responses, when carried out under professional guidance, serve as indicators of reserve a system has for that particular function. In the case of the sodium challenge, for example, a body in need of sodium (salt) will respond very positively with increased energy when salt is taken. A body that is overloaded may respond negatively with nausea and vomiting. A body with circulation and heart problems might lead to higher blood pressure or edema. A body that needs more sodium but are unable to balance fluid might respond with a mixed picture. An astute clinician will be able to use these qualitative results as a clinical guide to formulate a proper recovery program for that single item - sodium.
Salt craving is also used as a monitoring tool. As Adrenal Fatigue improves, salt craving usually reduces. Salt, therefore, serves multiple roles. It has challenge, therapeutic, and monitoring roles. Knowing how to use this single compound properly can give us a good sense of where the body stands not only as it relates to this one nutrient, but also on how it can relate to other nutrients as well. For example, sodium is tied to water and is inversely tied to potassium. Knowing sodium tolerance will give us information about how to manage potential fluid and potassium imbalances as well. This can be far more insightful than any laboratory test.
Challenges using different nutrients are deployed continually during the recovery phase to assess the effectiveness of current therapeutic agents, test the reaction to possible new agents prior to starting, and assess the clearance state. Continually using challenges to feel the path is like having a walking stick in hand to have a better assessment of what lies ahead prior to even putting your foot on the next rock. It makes the recovery process more pleasant, smooth and safe.
Generally, challenges involve the use of nutritional supplements, as their results are easily evident in most cases if done right. Challenges are generally divided into four broad categories:
It is very important not to equate a positive outcome of a challenge as the only way to a successful challenge. In certain cases, one might be looking for a negative response. In other words, not all challenges need to be positive in order to be a successful challenge. A successful challenge is one that elicits a certain response from the body that leads us to draw certain conclusions and thus a better formulation of the overall recovery plan. For example, a neutral response and absence of diarrhea when large doses of magnesium are administered would mean that body has yet to reach bowel tolerance level (BTL). If we wish to know the BTL, we want to elicit a negative response. In this case, we increase the magnesium load until diarrhea is experienced. Positive and negative results are closely monitored with respect to each specific nutrient relative to the challenge taken. The onset of anxiety and fatigue when DHEA is administered may indicate a low clearance state. A sense of a morning hangover after a melatonin challenge the night before may indicate circadian dysfunction or overload.
Almost any nutrient can be used as a challenge substrate. Prior to commencing any nutrient challenge, one should have an idea of the body's previous nutrient reaction history. For example, let us say a person has taken ascorbic acid before at 1000 mg without adverse effect. This neutral history serves to qualify ascorbic acid as a potential nutrient that can be used if it is selected to be part of the challenge toolbox. Those who cannot tolerate ascorbic acid because of gastric irritation, for example, will preclude the use of this nutrient as a challenge substrate. Challenges should not be started with a compound that was not previously exposed to the body due to the risk of possible negative reactions. A scaled approach is best if the body is constitutionally weak or low in clearance. For example, most people develop diarrhea when BTL is reached with high dose oral ascorbic acid. Because the BTL varies from person to person, one should start off with low doses and scale up accordingly. To use this nutrient at a dose above the BTL in the beginning would not yield any results other than diarrhea.
The many different forms of nutrients can also have its unique challenge characteristics. In the example above, ascorbic acid tends to be fast acting and "spiky". Its use as a challenge substrate is best when it is desirous to know how the adrenals react to clear compounds that are stimulatory. Fat-soluble vitamin C, due to its more gentle and slower absorption characteristics, for example, would not be a good substrate to use for this purpose. It is, however, an excellent challenge if one wants to study the effect of vitamin C in a body that is highly sensitive to regular ascorbic acid.
The identification of the possible pool of qualified nutrients therefore, depends on the history as well as from actual use of the nutrient in the clinical setting scaled to match the body's tolerance. A careful and detailed nutrient reaction history can serve as a good guide to start. Many with Adrenal Fatigue are already on a battery of natural compounds. Careful evaluation of these compounds on an individual basis can help to contribute to the entire selection process.
The list of challenge substrates is vast and varied. Every natural compound has its unique characteristics and use. Having a detail physiological understanding of each of these compounds is a key prerequisite prior to starting any nutrient challenge. An astute and experienced clinician is the key to this process due to the subtle differences among natural compounds that are not easy to detect.
Here are some nutrients and their possible uses as challenge substrates:
The dose necessary for a successful challenge varies greatly from nutrient to nutrient as well as from person to person. In the case of vitamin C, some can experience significant responses with as little as 10 mg, while others will need well over 10,000 mg. In addition to dosage, the delivery system has to be considered. Different forms of the same substrate also have different properties. Liquid form may be more desirable in certain situations as they tend to be absorbed faster into the blood stream. Topical forms of delivery system are particularly important when it comes to those who are highly sensitive.
It is also important to note that previously intolerable substrates may be reintroduced later again as a challenged nutrient and used as a yardstick of the recovery process. This tolerance challenge is clinically very useful.
It is very important to remember that while nutrients designed to be used during the challenge process may have positive therapeutic value, many nutrients are not suitable for long-term therapeutic use for a wide variety of reasons. For example, DHEA used during a challenge may help increase energy and reduce fatigue. Some will continue to use DHEA for a long period of time in order to have this energizing effect. However, long-term use may lead to excessive hair loss and acne as well due to the possible androgenic effect. Extrapolating a positive therapeutic outcome from the use of a challenge substrate into long-term use can be a major mistake.
Challenges can also be designed to assess and target specific systems. Each protocol is designed to assess the functional level of a body system. They involve the use of nutrients, dietary input, and lifestyle adjustments in combinations. Here are some examples:
Metabolic system may be assessed by way of carbohydrate or protein challenge. For example, taking more protein before bedtime can point to the body's metabolic state in the middle of the night when blood sugar level may be low. The response will point to the body's ability to process glucose. This can also be very useful in assessing those with metabolic syndrome, insulin resistance, hypoglycemia, or sleep maintenance insomnia.
Sympathetic nervous system function may be assessed by a forced deep breathing challenge or nutrients such as tyrosine and selected herbs. The response will point to the body's response to sympathetic overtone and its adrenaline state.
Ingesting hard-to-digest-proteins and its assimilation may assess the gastro-intestinal system. DHEA, glutamine, and magnesium are also valuable in assessing issues of irritable bowel and leaky gut. Due to the complicity and potential of negative and sometimes unpredictable responses, all challenges should be done only under experienced professional guidance in a controlled environment. Improper challenges can trigger adrenal crash and make Adrenal Fatigue worse.
With proper qualitative challenges, the clinician can gain valuable insights far beyond any laboratory test. This facilitates the formulation of a good recovery management program customized to the body's needs.
One key question remains - how long does the recovery take?
The duration of the Recovery Phase varies as it is dependent of the Adrenal Fatigue stage. The more advanced the Adrenal Fatigue stage, the longer will be the Recovery Phase.
Recovery factor (RF) is a quantitative measurement of the Recovery Phase duration relative to crash phase duration. This helps us to appreciate the time it takes for recovery vs. the time of the crash. RF is a numerical number derived by dividing the recovery time by the crash time. If the crash duration is 1 day and the subsequent recovery duration to return to immediate pre-crash baseline is 4 days, then RF = 4/1 = 4. In other words, it takes the body four times longer to recover relative to crash. The higher the RF number, the more depleted the adrenal reserve and the weaker the adrenal glands. RF ranges from 1-20, with the lowest number in stage 1 and the highest number in stage 4. RF gives us a rough measurement of one's adrenal function.
The RF number can vary due to tremendous individual variation. Note that as Adrenal Fatigue stage progresses, the average RF increases. The average RF for stage 2 is 2, while the average RF for stage 3C is 7. The RF range also increases. The RF range for stage two varies from 1 to 3, or a 3 fold range. The RF range for someone in stage 3D can range from 6 to 30, a 5 fold increase. Those at stage 3D can expect a recovery time of 30 times or longer compared to stage 1 Adrenal Fatigue. The weaker the adrenals, the wider the range with a bias towards slower and less than optimal recovery. It is rare to see anyone with RF of 3 in stage 3D Adrenal Fatigue unless under professional guidance. It is common for most in stage 3D to have RF from 6 to 30.
Another way to look at this: those in stage 1 Adrenal Fatigue can expect to spend 50% of the total cycle in crash and Recovery Phase each. As Adrenal Fatigue worsens, one can expect to spend a proportionally longer period of time in Recovery Phase relative to crash phase. A typical stage 3C sufferer can expect to spend about 13% of the total cycle time in the crash phase and 87% of the time in Recovery Phase. The following table depicts a summary of clinical observations. Each number represents a unit in time, usually day(s).
|Adrenal Fatigue Stage||Average Days of Adrenal Crash||Average Days it Takes to Recover||Ave. Total Cycle Time||Average Recovery Factor||Crash Time as % of Total Cycle||Recovery Time as % of Total Cycle||Recovery Factor Range|
|1||1||1||2||1||50||50||1 to 2|
|2||1.35||2.5||4||2||33||66||1 to 3|
|3A||2||5||8||3||25||75||2 to 6|
|3B||2||8||10||4||20||80||3 to 7|
|3C||2||14||16||7||13||87||4 to 10|
|3D||2||24||26||12||8||92||6 to 30|
In absolute terms, the RF increases greatly in Stage 3C as this is where the greatest functional decline occurs. The RF increases by 43% from Stage 3B to 3C vs. an increase of 33% from Stage 3A to 3B. This bias continues to be carried onward as one enters Stage 3D from 3C. It comes as no surprise that those in Stage 3D spend 92% of their time in recovery and only 8% in crash on average. It is therefore imperative that those with advance Adrenal Fatigue avoid crashes as much as possible.
The following graphs depict what a successful and a failed recovery program should look like.
Line A shows a normal crash of average intensity followed by a typical prolonged recovery time common in Adrenal Fatigue stage 3C. There are frequent setbacks during a slow and steady recovery.
Line B shows the same crash but under optimal recovery conditions. Such a recovery program does not guarantee a total absence of a crash. Intermittent crashes are unavoidable. A successful program, usually under experienced professional guidance, allows the sufferer a learning experience on how to recognize a crash before it comes, make available ahead of time customized tools so that if a crash does occur due to circumstances beyond control, there is immediate deployment of such tools to effect a slower and lower intensity crash. The goal is a less symptomatic crash, a "soft-landing". Some unpleasantness may be unavoidable, but the symptoms will be under control and manageable with no panic. The risk of rolling into another crash is minimized. It is not unusual to have a drastic reduction in crash frequency and symptoms if properly managed professionally. A successful program will also allow the sufferer to effect a much faster Recovery Phase and thus an overall shorter total cycle time. The shorter the cycle, the less unpleasantness and fatigue.
Line C this represents a failed program. Unfortunately most self-navigation programs fall into this category, especially for those with advanced Adrenal Fatigue or weak constitution. After the adrenal crash, recovery may appear to progress well. This is often due to administration of stimulatory compounds that include medications, herbs and glandular to sustain unrealistic adrenal function at a time when the adrenals needs to be nurtured with a carefully customized program specific for the body's need. Programs using stimulatory compounds (natural or prescription) may lead to outcome that appears to improve for a short time. The unsuspected sufferer is mislead into thinking that the right recovery path has been chosen. This false sense of improvement eventually fades as symptoms not only return but also become worse, resulting in a more severe second crash as the body cannot handle prolonged stimulation. This second crash often leads to a lower state of adrenal function below that of previous crash, setting a new low. This downward cascade is repeated far too often, and with each failure, the body becomes weaker. These crashes propel the body into advanced stages of Adrenal Fatigue that could have been avoided if a good recovery program has been followed early on.
While recovery phases of stage 1 and 2 Adrenal Fatigue are relatively uneventful, those in Stage 3 Adrenal Fatigue (Adrenal Exhaustion) usually find recovery very challenging. The body's intrinsic constitution plays a big role in determining the Recovery Phase outcome. The more advance the Adrenal Fatigue, the more varied is the recovery pattern. This is especially true of those in stage 3C or 4 Adrenal Fatigue. Those who have strong adrenal constitution do recover faster and the recovery is sustained when compared to those who have weak adrenals. Those with very weak constitution and severe stress may suffer crashes and never fully recover but continue going downward in a path of decompensation. There is no laboratory test to forecast the body's constitution. Knowing whether you have a strong, normal or weak body constitution plays an important role in Adrenal Fatigue recovery planning because the pattern of recovery and the kind of nutrients required differ depending on the type of body constitution. The more advanced the Adrenal Fatigue, the more important the body constitution plays a role in determining the ultimate natural progression of the condition.
The following depicts how the body's intrinsic adrenal constitution affects the recovery pattern in people suffering from stage 3C Adrenal Fatigue:
Nowhere is it more important to study the recovery pattern than in Adrenal Fatigue Stage 3, especially Phase C because of the variety of possible recovery outcome. The natural progression for those with normal constitution is one of slow deterioration over a period of time (Pattern 5). However, the time can be lengthened if the intrinsic body constitution is strong (Pattern 6). The goal is to extend the time as long as possible and the deterioration pattern to be slowed as much as possible. This is best achieved by a personalized recovery program (Pattern 7). Those with very weak constitution tend to fair worse (Pattern 1).
Unfortunately, excessive and inappropriate use of natural stimulatory compounds commonly employed by those who are in self-navigating mode (Pattern 3), as well as the aggressive use of prescription medications (Pattern 4), often worsen the final outcome of many Adrenal Exhaustion recovery cases. Eventually, this will push the sufferer into adrenal failure far earlier than if nothing is being done and let nature takes its course (Pattern 5). In other words, matters are often made even worse.
Fortunately, regardless of which recovery pattern is being followed, the body is generally forgiving. The key is to mimic the recovery curve as close as possible to Pattern 7. With the right professional help, the body's damage can often be reversed and nurtured back to health.
The following table summarizes the above discussion:
It is easy to identify a major adrenal crash by the various symptoms. There is no mistake when a crash occurs unless it very minor. The majority of pre-crash symptoms are exacerbated and magnified greatly. Recovery, however, is much less obvious and can be confusing. It comes on insidiously, slowly and often time marred with setbacks. This is made more complicated if the body's constitution is weak. The signs are sometimes hard to detect, and often only become evident with time. Paradoxical symptoms are common, especially for those with weak constitution. Only with long clinical experience, attention to detail, and retrospect does one see a Recovery Phase with clarity.
While most Adrenal Fatigue sufferers are familiar with adrenal crash from personal experiences, most are unfamiliar with the importance of the Recovery Phase of the cycle. A recovery may be real, or maybe a prelude of a forthcoming crash in disguise. In other words, the worse may be over, but it may be yet to come. The ability to recognize whether the body is following an accelerated, normal or delayed recovery curve as well as whether the body's constitution strong or weak all play important roles to a properly formulated recovery plan.
The management of adrenal crash and adrenal recovery are very different. Administration of nutrients and adjustment of dosages designed to help recovery, if dispensed improperly during the crash phase, may in fact worsen the crash. On the converse, proper application of nutrients during the crash phase can lead to a softer landing and faster recovery. Under expert management, adrenal crash may also present as an opportunity to help the body propel directly into the honeymoon period, bypassing the stabilization and preparation period.
Similarly, nutrients required during recovery can be very different from those during the adrenal crash. The focuses are different not only as it relates to crash vs. recovery, but also as it related to each person's unique constitution. During adrenal crash, the focus is to avoid further damage and soften the crash intensity. During the Recovery Phase, the focus is to deploy nutrients to fortify the adrenals to the degree that they can tolerate and clear from the body without triggering another crash due to the often-associated low clearance state. Sometimes the nutrient dosage needs to be reduced during the adrenal crash phase and increased during the Recovery Phase. Other times, it is the reverse. Administering the wrong nutrient and dosage at the wrong time will only worsen the overall Adrenal Fatigue and delay recovery. Understanding the recovery cycle and using properly designed challenges during the right time of the recovery greatly facilitate the overall healing process.
In addition, a careful study of the Recovery Phase of the cycle is critical because the speed and character of the Recovery Phase as shown by the recovery curve is a direct reflection of the amount of adrenal reserve remaining after a crash. Some people recover relatively quickly compared to others. Younger sufferers and those who are constitutionally strong tend to recover faster and can tolerate a stronger support of nutrients, while too strong a nutritional support during Recovery Phase can trigger adrenal crash among others, especially those who are constitutionally weak. The common mistake seen in many self-guided recovery programs is the administration of excessive nutrients under the mistaken belief that more may be better. The many recovery characteristics shown by the body is the only way the body knows how to express the overall adrenal capacity and the degree of decompensation as a result of a crash. A detailed study of the recovery and its various components allows us to understand the many paradoxical reactions that are common during crashes and the ways to avoid them in the future in relation to the specific body. Generally speaking, the stronger the adrenal function remains after the crash, the shorter the Recovery Phase and the closer the post-crash energy level is to the immediate pre-crash baseline. It is the careful attention to the recovery cycle that gives us the markers and thus the ability to design a proper recovery program with accuracy and confidence in order to facilitate maximum healing. The current Recovery Phase curve helps us to formulate preventive measures so that the next crash, should it happen, is shorter, gentler, and the ensuing recovery faster.
Those who do not pay attention to the lessons learned from the Recovery Phase invariably will miss important clinical perils and thus lack a plan to handle future crashes. The result is invariably a body that is subjected to repeated crashes over time.
One of the most difficult and perplexing challenges for clinicians and Adrenal Fatigue sufferers is the management of adrenal crash and recovery cycles. Crashes are triggers that bring sufferers to their physicians in the first place, and they will continue to haunt the sufferer throughout the duration of this condition until their adrenal functions become normalized.
Unfortunately, most inexperienced clinicians and self-navigation efforts fail because of the failure to fully understand the significance of the crash and its subsequent Recovery Phase in detail. The body is communicating to us constantly. With each crash and recovery, signals are sent by the body in the form of signs and symptoms. Clinical excellence requires a detailed investigation and examination into the cause of each crash. Combining this with a careful clinical study of the pre-crash status of adrenal function will give an experienced clinician a better understanding of remaining adrenal reserve and capacity. A clearer picture will generally begin to emerge and one will no longer be dumb-founded at why a crash happens in the first place. The body is logical after all, if only we look deeper.
Understanding the crash and recovery cycle in detail and their characteristics will help the clinician and sufferer better manage the crash as it happens, prepare a soft landing, set a realistic recovery time, and select the proper tools to effect maximum adrenal healing in the shortest time with minimum risk of triggering a subsequent crash. It also helps the sufferer to understand the natural progression of Adrenal Fatigue and to have realistic expectations of the road ahead.
BCP are designed to regulate menstrual flow. Advanced sufferers of AFS can find hormonal rebalancing destabilizing which can trigger an adrenal crash. This is not common, however.
Any crash is not healthy for the mother and the fetus because it requires the body to expand its resources for recovery which would drain the existing resources. Remember there are no good crashes. Therefore it is imperative for those who are pregnant to take good rest and nurture the body as much as possible.